Automated description from the Alliance of Genome Resources (Release 7.1.0)
Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity and single-stranded DNA binding activity. Involved in several processes, including endodermal cell fate commitment; negative regulation of transcription by RNA polymerase II; and stem cell population maintenance. Acts upstream of or within blastocyst growth. Located in nucleolus. Part of Cdc73/Paf1 complex. Is expressed in several structures, including brain and retina nuclear layer. Used to study dilated cardiomyopathy. Orthologous to human RTF1 (RTF1 homolog, Paf1/RNA polymerase II complex component).