Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; limb bud; metanephros; pancreas; and surface ectoderm. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase).