Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and histone modifying activity. Involved in several processes, including circadian regulation of gene expression; eyelid development in camera-type eye; and negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including cellular response to trichostatin A; nervous system development; and regulation of signal transduction. Located in nucleus and replication fork. Part of RNA polymerase II transcription repressor complex and heterochromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human HDAC2 (histone deacetylase 2).