Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including circulatory system development; regulation of transcription by RNA polymerase II; and trophoblast giant cell differentiation. Located in nucleolus and nucleoplasm. Is expressed in several structures, including alimentary system; early conceptus; heart and pericardium; nervous system; and urinary system. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1).