SAMP10

Characteristics:

Shows accelerated aging.All mice over 8 months have amyloidosis and about 78% of mice over 10 months have contracted kidneys. Median survival time in conventional conditions is 333 days. (Takeda et al 1991). Spontaneous brain atrophy with advancing age. This is most marked in the frontal cortex, and other neocortical regions develop diffuse atrophy. Age-related loss of neocortical neurones is evident (Shimada et al 1992), and correlates with deficits in learning (Shimada et al 1993). Aged garlick oil prevents the development of atrophic changes in the frontal brain at 12 months (Moriguchi et al, 1997).

Shimada A., Ohta A., Akiguchi I., and Takeda T. (1993) Age-related deterioration in condition avoidance taks in the SAM-P/10 mouse, an animal model for spontaneous brain atrophy. Brain Res. 608, 266-272.

Takeda T., Hosokawa M., and Higuchi K. (1991) Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J. Amer. Geriatr. Soc. 39, 911-919.