Inbred Strains
of Mice: PRO
Inbr: F61 (Brk). Genet:
a, cch, p.
Origin: E. S. Russell, 129/ReJ x C57BL/6J. Sib-mating with selection for
a, cch and
p.
Mutation to
Pro1b (proline oxidase-1)
which controls activity level of proline oxidase in liver, kidney, and
brain, which is about 20% of normal in this strain. 7 and 50 fold elevation
of proline in blood and urine, respectively.
Characteristics
Hyperprolinaemia and prolinuria with increased taurine excretion (
Blake et al., 1974., 1974); sluggish movements, 50% generalised
hair loss (
Kanwar et al., 1975., 1975).
Hyperprolinaemia due to a deficiency in the activity of component 1 of
mitochondrial proline dehydrogenase (
Blake
et al., 1976., 1976), and associated with a decreased liver proline
oxidase activity (
Blake, 1972). High lymphocyte
phyto-haemagglutinin response (8/43) (
Heiniger
et al., 1975., 1975).
Blake R.
L., Grillo R. V., and Russell E. S. (1974) Increased taurine excretion
in hereditary hyperprolinemia of the mouse. Life Sci. 14,
1285-1290.
Blake R.
L., Hall J. G., and Russell E. S. (1976) Mitochondrial proline dehydrogenase
deficiency in hyperprolinemic PRO/Re mice: Genetic and enzymatic analyses.
Biochem. Genet. 14, 739-757.
Blake R. L. (1972) Animal
model for hyperprolinaemia: deficiency of mouse proline oxidase activity.
Biochem. J. 129, 987-989.
Heiniger
H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of
the phytohaemagglutinin responsiveness of lymphocytes and its relationship
to leukemogenesis. Cancer Res. 35, 825-831.
Kanwar
Y. S., Krakower C. A., Manaligod J. R., Justice P., and Wong P. W. K.
(1975) Biochemical, morphological and hybrid studies in hyperprolinemic
mice. Biomedicine 22, 209-216.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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