|
Symbol Name ID |
Shh
sonic hedgehog MGI:98297 |
| Darker colors indicate more annotations |
| Human Phenotypes | Postaxial hand polydactyly |
Complete duplication of distal phalanx of the thumb |
Camptodactyly of finger |
Broad thumb |
Duplication of thumb phalanx |
Hand polydactyly |
Preaxial hand polydactyly |
Dysplastic distal thumb phalanges with a central hole |
Triphalangeal thumb |
Opposable triphalangeal thumb |
Adducted thumb |
Aplasia/Hypoplasia of the thumb |
Postaxial foot polydactyly |
Duplication of phalanx of hallux |
Broad hallux |
Preaxial foot polydactyly |
Foot polydactyly |
Toe syndactyly |
1-5 toe syndactyly |
2-3 toe syndactyly |
Cutaneous syndactyly of toes |
Polydactyly |
Postaxial polydactyly |
Preaxial polydactyly |
Brachydactyly |
Syndactyly |
Cutaneous finger syndactyly |
1-5 finger complete cutaneous syndactyly |
1-5 finger syndactyly |
3-4 finger syndactyly |
Abnormal fibula morphology |
Fibular duplication |
Aplasia/Hypoplasia of the tibia |
Absent tibia |
Short tibia |
Patellar aplasia |
Supernumerary metacarpal bones |
6 metacarpals |
Y-shaped metacarpals |
Talipes |
Synostosis of carpal bones |
| Disease(s) Associated with SHH | |||||||||||||||||||||||||||||||||||||||||
| Hirschsprung's disease | |||||||||||||||||||||||||||||||||||||||||
| holoprosencephaly | |||||||||||||||||||||||||||||||||||||||||
| hypoplastic or aplastic tibia with polydactyly | |||||||||||||||||||||||||||||||||||||||||
| polydactyly | |||||||||||||||||||||||||||||||||||||||||
| syndactyly type 4 |
| Mouse Phenotypes | abnormal limb morphology |
abnormal autopod morphology |
abnormal carpal bone morphology |
abnormal digit morphology |
adactyly |
oligodactyly |
polydactyly |
polysyndactyly |
syndactyly |
abnormal tarsal bone morphology |
abnormal humerus morphology |
abnormal forelimb zeugopod morphology |
absent forelimb |
abnormal hindlimb zeugopod morphology |
absent fibula |
absent tibia |
absent hindlimb |
abnormal limb bone morphology |
abnormal limb development |
short limbs |
kinked tail |
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| Availability | Mouse Genotype | |||||||||||||||||||||
| Shhtm1(EGFP/cre)Cjt/Shhtm1(EGFP/cre)Cjt | ||||||||||||||||||||||
| Shhtm1Chg/Shhtm1Chg | ||||||||||||||||||||||
| Shhtm1Ptch/Shhtm1Ptch | ||||||||||||||||||||||
| Tg(KRT14-Shh)#Cobm/0 | ||||||||||||||||||||||
| Shhtm1Chg/Shhtm2Chg Edil3Tg(Sox2-cre)1Amc/Edil3+ (conditional) |
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| Shhtm2Chg/Shh+ Edil3Tg(Sox2-cre)1Amc/Edil3+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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