Symbol
Name
ID

Scn1a
sodium channel, voltage-gated, type I, alpha
MGI:98246

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Drooling	Gastrostomy tube feeding in infancy	Photophobia	Autistic behavior	Obsessive-compulsive trait	Impulsivity	Motor stereotypy	Phonophobia
Disease(s) Associated with SCN1A	Drooling	Gastrostomy tube feeding in infancy	Photophobia	Autistic behavior	Obsessive-compulsive trait	Impulsivity	Motor stereotypy	Phonophobia
developmental and epileptic encephalopathy 6B
Dravet syndrome
familial hemiplegic migraine 3
generalized epilepsy with febrile seizures plus

Mouse Phenotypes

behavior/neurological phenotype

increased susceptibility to pharmacologically induced seizures

impaired contextual conditioning behavior

abnormal habituation to a novel odor

impaired spatial learning

abnormal long-term spatial reference memory

abnormal spatial working memory

abnormal olfactory behavior

abnormal response to novel odor

increased anxiety-related response

increased thigmotaxis

abnormal response to novel object

abnormal response to social novelty

increased grooming behavior

abnormal involuntary movement

abnormal postural reflex

impaired righting response

tremors

ataxia

jerky movement

abnormal posture

head bobbing

akinesia

abnormal gait

decreased locomotor activity

increased locomotor activity

hyperactivity

circling

abnormal nest building behavior

abnormal social investigation

seizures

maximal tonic hindlimb extension seizures

environmentally induced seizures

convulsive seizures

clonic seizures

tonic seizures

tonic-clonic seizures

abnormal spike wave discharge

Availability

Mouse Genotype

Scn1a^em1Anord/Scn1a^em1Anord

Scn1a^tm1.1Aesc/Scn1a^tm1.1Aesc

Scn1a^tm1.1Swl/Scn1a^tm1.1Swl

Scn1a^tm1Kzy/Scn1a^tm1Kzy

Scn1a^tm1Wac/Scn1a^tm1Wac

Scn1a^tm2.2Kzy/Scn1a^tm2.2Kzy

Scn1a^em1Anord/Scn1a⁺

Scn1a^tm1.1Aesc/Scn1a⁺

Scn1a^tm1.1Kzy/Scn1a⁺

Scn1a^tm1.1Swl/Scn1a⁺

Scn1a^tm1Kea/Scn1a⁺

Scn1a^tm1Kzy/Scn1a⁺

Scn1a^tm1Wac/Scn1a⁺

Scn1a^tm2.2Kzy/Scn1a⁺

Tg(Scn1a*)RH9Aesc/0

Scn1a^tm2.1Kzy/Scn1a^tm2.1Kzy
Tg(Slc32a1-cre)65Kzy/0 (conditional)

Emx1^{tm1.1(cre)Ito}/Emx1⁺
Scn1a^tm2.1Kzy/Scn1a^tm2.1Kzy (conditional)

Emx1^{tm1.1(cre)Ito}/Emx1⁺
Scn1a^tm2.1Kzy/Scn1a^tm2.1Kzy
Tg(Slc32a1-cre)65Kzy/0 (conditional)

Scn1a^tm2.1Kzy/Scn1a^tm2.1Kzy
Tg(Pvalb-cre)1Tama/0 (conditional)

Scn1a^tm2.1Kzy/Scn1a⁺
Tg(Slc32a1-cre)65Kzy/0 (conditional)

Scn1a^tm2.1Kzy/Scn1a⁺
Tg(Pvalb-cre)1Tama/0 (conditional)

Scn1a^tm2.1Wac/Scn1a⁺
Tg(I12b-cre)1Jlr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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