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Symbol
Name
ID

Prf1
perforin 1 (pore forming protein)
MGI:97551

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Reduced natural killer cell activity
Disease(s) Associated with PRF1	Reduced natural killer cell activity
familial hemophagocytic lymphohistiocytosis 2

Mouse Phenotypes		decreased T cell apoptosis	lymph node necrosis	decreased NK cell degranulation
Availability	Mouse Genotype	decreased T cell apoptosis	lymph node necrosis	decreased NK cell degranulation
	Prf1^tm1Sdz/Prf1^tm1Sdz
	Prf1^tm1Tsc/Prf1^tm1Tsc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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