Symbol
Name
ID

Smad4
SMAD family member 4
MGI:894293

Phenotype annotations related to embryo

Darker colors indicate more annotations

Mouse Phenotypes

abnormal vitelline vasculature morphology

decreased inner cell mass proliferation

decreased embryonic epiblast cell proliferation

abnormal embryo development

abnormal dorsal-ventral axis patterning

abnormal ectoderm development

abnormal endoderm development

abnormal mesoderm development

failure to gastrulate

abnormal proximal-distal axis patterning

abnormal rostral-caudal axis patterning

rostral body truncation

embryonic growth arrest

embryonic growth retardation

decreased embryo size

abnormal embryonic tissue morphology

abnormal embryonic epiblast morphology

absent egg cylinders

absent mesoderm

abnormal rhombomere morphology

failure of primitive streak formation

fused somites

abnormal embryonic-extraembryonic boundary morphology

small ectoplacental cone

abnormal extraembryonic tissue morphology

abnormal allantois morphology

increased Reichert's membrane thickness

disorganized extraembryonic tissue

abnormal embryonic hematopoiesis

abnormal visceral endoderm morphology

absent anterior visceral endoderm

Availability

Mouse Genotype

Smad4^E6sad/Smad4^E6sad

Smad4^m4Mag/Smad4^m4Mag

Smad4^tm1.1Rob/Smad4^tm1.1Rob

Smad4^tm1Cxd/Smad4^tm1Cxd

Smad4^tm1Mak/Smad4^tm1Mak

Smad4^m4Mag/Smad4^tm1Cxd

Smad4^tm2.1Cxd/Smad4^tm2.1Cxd
Kdr^tm1(cre)Sato/Kdr⁺ (conditional)

Smad4^tm1Rob/Smad4^tm1.1Rob
Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ (conditional)

Smad4^tm1Rdp/Smad4^tm1.1Rdp
Tg(CAG-cre)13Miya/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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