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Symbol
Name
ID

Mir140
microRNA 140
MGI:2676825

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Retrognathia	Cone-shaped epiphyses of the phalanges of the hand	Arachnodactyly	Brachydactyly	Small hand	Delayed epiphyseal ossification	Abnormal sternum morphology	Scoliosis
Disease(s) Associated with MIR140	Retrognathia	Cone-shaped epiphyses of the phalanges of the hand	Arachnodactyly	Brachydactyly	Small hand	Delayed epiphyseal ossification	Abnormal sternum morphology	Scoliosis
spondyloepiphyseal dysplasia Nishimura type
thoracic aortic aneurysm

Mouse Phenotypes

skeleton phenotype

abnormal basicranium morphology

small basisphenoid bone

decreased cranium height

short maxilla

short nasal bone

domed cranium

decreased susceptibility to induced arthritis

increased susceptibility to induced arthritis

osteoarthritis

short femur

short tibia

abnormal skeleton morphology

abnormal long bone epiphyseal plate morphology

increased width of hypertrophic chondrocyte zone

decreased long bone epiphyseal plate size

decreased length of long bones

platyspondylia

small vertebral body

abnormal cartilage development

abnormal skeleton development

abnormal epiphyseal plate morphology

abnormal skeleton physiology

decreased bone mineralization

delayed bone ossification

abnormal chondrocyte physiology

Availability

Mouse Genotype

Mir140^em1Asah/Mir140^em1Asah

Mir140^em1Tkob/Mir140^em1Tkob

Mir140^tm1.1Asah/Mir140^tm1.1Asah

*

Mir140^tm1.1Tkob/Mir140^tm1.1Tkob

Mir140^em1Tkob/Mir140⁺

Tg(Col2a1-Mir140)#Asah/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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