Symbol
Name
ID

Nlrp3
NLR family, pyrin domain containing 3
MGI:2653833

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Abnormality of metabolism/homeostasis	Elevated circulating C-reactive protein concentration	Elevated erythrocyte sedimentation rate	Edema	Lymphedema	Fever	Recurrent fever	Periodic fever	Renal amyloidosis	Chills
Disease(s) Associated with NLRP3	Abnormality of metabolism/homeostasis	Elevated circulating C-reactive protein concentration	Elevated erythrocyte sedimentation rate	Edema	Lymphedema	Fever	Recurrent fever	Periodic fever	Renal amyloidosis	Chills
autosomal dominant nonsyndromic deafness 34
CINCA Syndrome
familial cold autoinflammatory syndrome 1
Muckle-Wells syndrome

Mouse Phenotypes

increased susceptibility to diet-induced obesity

abnormal circulating cytokine level

abnormal circulating chemokine level

decreased circulating interleukin-1 beta level

increased circulating interleukin-1 beta level

decreased circulating interleukin-12b level

increased circulating interleukin-13 level

decreased circulating interleukin-18 level

increased circulating interleukin-18 level

increased circulating interleukin-3 level

increased circulating interleukin-4 level

decreased circulating interleukin-5 level

increased circulating interleukin-6 level

increased circulating interleukin-9 level

increased circulating tumor necrosis factor level

decreased energy expenditure

decreased lactate dehydrogenase level

increased liver triglyceride level

abnormal lipid metabolism

Availability

Mouse Genotype

Nlrp3^tm1Bhk/Nlrp3^tm1Bhk

Nlrp3^tm1Flv/Nlrp3^tm1Flv

Nlrp3^tm1Vmd/Nlrp3^tm1Vmd

Nlrp3^tm3.1Hhf/Nlrp3⁺

Nlrp3^tm1Hhf/Nlrp3⁺
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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