Symbol
Name
ID

Dhtkd1
dehydrogenase E1 and transketolase domain containing 1
MGI:2445096

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	2-hydroxyadipic aciduria	Alpha-aminoadipic aciduria
Disease(s) Associated with DHTKD1	2-hydroxyadipic aciduria	Alpha-aminoadipic aciduria
2-aminoadipic 2-oxoadipic aciduria

Mouse Phenotypes

impaired exercise endurance

increased insulin secretion

decreased circulating glucose level

increased circulating insulin level

increased circulating insulin-like growth factor I level

decreased circulating cholesterol level

decreased circulating glycerol level

increased circulating phospholipid level

decreased circulating triglyceride level

increased circulating creatine kinase level

increased circulating lactate dehydrogenase level

increased respiratory quotient

improved glucose tolerance

increased liver glycogen level

increased insulin sensitivity

aciduria

abnormal amino acid metabolism

Availability

Mouse Genotype

Dhtkd1^em1Hpr/Dhtkd1^em1Hpr

Dhtkd1^tm1Mmgu/Dhtkd1^tm1Mmgu

Dhtkd1^tm1Zgwg/Dhtkd1^tm1Zgwg

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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