Symbol
Name
ID

Mcph1
microcephaly, primary autosomal recessive 1
MGI:2443308

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Increased rate of premature chromosome condensation
Disease(s) Associated with MCPH1	Increased rate of premature chromosome condensation
primary autosomal recessive microcephaly 1

Mouse Phenotypes

abnormal spermatid morphology

decreased male germ cell number

abnormal chromosome morphology

abnormal cell cycle

abnormal male meiosis

arrest of male meiosis

abnormal mitosis

abnormal mitotic spindle morphology

increased cellular sensitivity to gamma-irradiation

increased male germ cell apoptosis

increased neuron apoptosis

abnormal neuron differentiation

abnormal neuronal precursor proliferation

chromosomal instability

induced chromosome breakage

Availability

Mouse Genotype

Mcph1^{Gt(RRO608)Byg}/Mcph1^{Gt(RRO608)Byg}

Mcph1^tm1.1Zqw/Mcph1^tm1.1Zqw

Mcph1^tm1.2Kali/Mcph1^tm1.2Kali

Mcph1^{tm1a(EUCOMM)Wtsi}/Mcph1^{tm1a(EUCOMM)Wtsi}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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