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transmembrane protease, serine 3
Phenotype annotations related to hearing/vestibular/ear
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Sensorineural hearing impairment
Disease(s) Associated with TMPRSS3
autosomal recessive nonsyndromic deafness 8

Mouse Phenotypes
hearing/vestibular/ear phenotype
abnormal kinocilium morphology
abnormal cochlea morphology
absent cochlear hair cells
absent cochlear inner hair cells
absent cochlear outer hair cells
abnormal inner hair cell stereociliary bundle morphology
abnormal outer hair cell stereociliary bundle morphology
cochlear inner hair cell degeneration
cochlear outer hair cell degeneration
cochlear hair cell degeneration
abnormal organ of Corti morphology
organ of Corti degeneration
abnormal stria vascularis morphology
absent vestibular hair cells
vestibular hair cell degeneration
abnormal vestibular saccule morphology
increased or absent threshold for auditory brainstem response
absent distortion product otoacoustic emissions
abnormal vestibular system physiology
Availability Mouse Genotype
Tmprss3m1Ingm/Tmprss3m1Ingm *

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory