About Help FAQ

Symbol
Name
ID

Appl1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
MGI:1920243

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Maturity-onset diabetes of the young
Disease(s) Associated with APPL1	Diabetes mellitus	Maturity-onset diabetes of the young
maturity-onset diabetes of the young type 14

Mouse Phenotypes		homeostasis/metabolism phenotype	increased fasting circulating glucose level	increased circulating insulin level	increased core body temperature	impaired glucose tolerance	insulin resistance	abnormal hepatic glucose production
Availability	Mouse Genotype	homeostasis/metabolism phenotype	increased fasting circulating glucose level	increased circulating insulin level	increased core body temperature	impaired glucose tolerance	insulin resistance	abnormal hepatic glucose production
	Appl1^{Gt(RRS819)Byg}/Appl1^{Gt(RRS819)Byg}	*
	Appl1^Gt(XM073)Byg/Appl1^Gt(XM073)Byg	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/09/2026 MGI 6.24