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Symbol
Name
ID

Afg3l2
AFG3-like AAA ATPase 2
MGI:1916847

Phenotype annotations related to cellular

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormal activity of mitochondrial respiratory chain
Disease(s) Associated with AFG3L2	Abnormal activity of mitochondrial respiratory chain
spinocerebellar ataxia type 28

Mouse Phenotypes		cellular phenotype	abnormal mitochondrial morphology	abnormal mitochondrial crista morphology	abnormal neuron mitochondrial morphology	abnormal Purkinje cell mitochondrial morphology	increased mitochondrial size	abnormal cellular respiration	abnormal respiratory electron transport chain	abnormal mitochondrial ATP synthesis coupled electron transport	oxidative stress
Availability	Mouse Genotype	cellular phenotype	abnormal mitochondrial morphology	abnormal mitochondrial crista morphology	abnormal neuron mitochondrial morphology	abnormal Purkinje cell mitochondrial morphology	increased mitochondrial size	abnormal cellular respiration	abnormal respiratory electron transport chain		oxidative stress
	Afg3l2^Emv66/Afg3l2^Emv66	*
	Afg3l2^par/Afg3l2^par	*
	Afg3l2^Emv66/Afg3l2⁺
	Afg3l2^tm1Arte/Afg3l2^tm1Arte Tg(Pcp2-cre)2Mpin/0 (conditional)
	Afg3l2^tm1Arte/Afg3l2^tm1Arte Tg(Plp1-cre/ERT)3Pop/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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