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Symbol
Name
ID
Wls
wntless WNT ligand secretion mediator
MGI:1915401
Phenotype annotations related to limbs/digits/tail
Darker colors indicate more annotations
Human Phenotypes
Broad distal phalanx of finger
Long fingers
Hypoplasia of the phalanges of the toes
Toe syndactyly
Ectrodactyly
Disease(s) Associated with WLS
Zaki syndrome

Mouse Phenotypes
abnormal apical ectodermal ridge morphology
thin apical ectodermal ridge
abnormal tail bud morphology
decreased autopod size
adactyly
oligodactyly
abnormal forelimb morphology
abnormal forelimb stylopod morphology
abnormal hindlimb morphology
abnormal hindlimb zeugopod morphology
short fibula
short tibia
abnormal limb development
abnormal digit development
short limbs
decreased caudal vertebrae number
Availability Mouse Genotype
Wlsem1Jgg/Wlsem1Jgg
Wlsem2Jgg/Wlsem2Jgg
Wlstm1Xzg/Wlstm1Xzg
Tg(Msx2-cre)5Rem/0  (conditional)
Wlstm1Xzg/Wlstm1Xzg
Tg(Prrx1-cre)1Cjt/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory