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Symbol Name ID |
Aifm1
apoptosis-inducing factor, mitochondrion-associated 1 MGI:1349419 |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased activity of mitochondrial complex IV |
Increased serum pyruvate |
Elevated circulating creatine kinase concentration |
Increased CSF lactate |
Elevated circulating hepatic transaminase concentration |
Increased circulating lactate dehydrogenase concentration |
Increased circulating lactate concentration |
| Disease(s) Associated with AIFM1 | |||||||
| Charcot-Marie-Tooth disease X-linked recessive 4 | |||||||
| combined oxidative phosphorylation deficiency 6 |
| Mouse Phenotypes | abnormal response to cardiac infarction |
increased myocardial infarct size |
decreased susceptibility to neuronal excitotoxicity |
increased circulating lactate level |
abnormal enzyme/coenzyme level |
increased superoxide dismutase level |
abnormal glucose homeostasis |
abnormal hormone level |
decreased catalase activity |
increased catalase activity |
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| Availability | Mouse Genotype | ||||||||||
| Aifm1Hq/Aifm1Hq | |||||||||||
| Aifm1Hq/Y | |||||||||||
| Aifm1tm2Pngr/Y Foxg1tm1(cre)Skm/Foxg1+ (conditional) |
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| Aifm1tm2Pngr/Y Tg(Ckmm-cre)5Khn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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