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Symbol
Name
ID

Mthfd1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
MGI:1342005

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormality of metabolism/homeostasis	Type II diabetes mellitus	Edema	Hydrops fetalis
Disease(s) Associated with MTHFD1	Abnormality of metabolism/homeostasis	Type II diabetes mellitus	Edema	Hydrops fetalis
developmental cardiac valvular defect
Down syndrome
neural tube defect

Mouse Phenotypes		homeostasis/metabolism phenotype	abnormal amino acid level	decreased circulating serum albumin level	abnormal enzyme/coenzyme level	abnormal folic acid level	abnormal nucleotide metabolism
Availability	Mouse Genotype	homeostasis/metabolism phenotype	abnormal amino acid level	decreased circulating serum albumin level	abnormal enzyme/coenzyme level	abnormal folic acid level	abnormal nucleotide metabolism
	Mthfd1^Gt(XB175)Byg/Mthfd1⁺
	Mthfd1^tm1.1Rzn/Mthfd1⁺	*
	Mthfd1^{tm2b(KOMP)Wtsi}/Mthfd1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23