|
Symbol Name ID |
Bscl2
BSCL2 lipid droplet biogenesis associated, seipin MGI:1298392 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hypertriglyceridemia |
Elevated circulating hepatic transaminase concentration |
Insulin-resistant diabetes mellitus at puberty |
Type II diabetes mellitus |
Hyperinsulinemia |
Hepatic steatosis |
Decreased serum leptin |
| Disease(s) Associated with BSCL2 | |||||||
| congenital generalized lipodystrophy type 2 |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
decreased susceptibility to diet-induced obesity |
increased fasting circulating glucose level |
decreased circulating glucose level |
increased circulating glucose level |
hyperglycemia |
increased circulating insulin level |
decreased circulating leptin level |
increased circulating HDL cholesterol level |
increased circulating cholesterol level |
decreased circulating free fatty acids level |
increased circulating free fatty acids level |
decreased circulating glycerol level |
increased circulating glycerol level |
decreased circulating triglyceride level |
increased circulating triglyceride level |
increased circulating calcium level |
increased circulating phosphate level |
increased circulating alanine transaminase level |
increased circulating alkaline phosphatase level |
increased circulating aspartate transaminase level |
increased circulating serum albumin level |
increased circulating total protein level |
increased body temperature |
decreased energy expenditure |
decreased carbon dioxide production |
decreased oxygen consumption |
decreased respiratory quotient |
increased respiratory quotient |
abnormal glucose homeostasis |
impaired glucose tolerance |
improved glucose tolerance |
insulin resistance |
decreased circulating adiponectin level |
abnormal lipid homeostasis |
abnormal phospholipid level |
abnormal triglyceride level |
increased liver triglyceride level |
enhanced lipolysis |
abnormal lipid metabolism |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||
| Bscl2tm1.1Lchan/Bscl2tm1.1Lchan | |||||||||||||||||||||||||||||||||||||||||
| Bscl2tm1.2Gliu/Bscl2tm1.2Gliu | |||||||||||||||||||||||||||||||||||||||||
| Bscl2tm1b(EUCOMM)Hmgu/Bscl2tm1b(EUCOMM)Hmgu | |||||||||||||||||||||||||||||||||||||||||
| Bscl2tm1Geno/Bscl2tm1Geno | * | ||||||||||||||||||||||||||||||||||||||||
| Bscl2tm1.1Gliu/Bscl2tm1.1Gliu Tg(Ddx4-cre)1Dcas/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||||||||
| Bscl2tm1.1Gliu/Bscl2tm1.1Gliu Tg(Fabp4-cre)1Rev/0 (conditional) |
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| Bscl2tm1c(EUCOMM)Hmgu/Bscl2tm1c(EUCOMM)Hmgu Tg(Adipoq-cre)1Evdr/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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