Symbol
Name
ID

Tnfaip3
tumor necrosis factor, alpha-induced protein 3
MGI:1196377

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Recurrent fever
Disease(s) Associated with TNFAIP3	Recurrent fever
familial Behcet-like autoinflammatory syndrome

Mouse Phenotypes

impaired adaptive thermogenesis

decreased fasting circulating glucose level

decreased circulating luteinizing hormone level

increased circulating insulin level

increased circulating progesterone level

abnormal circulating cytokine level

increased circulating interferon-gamma level

abnormal circulating interleukin level

increased circulating interleukin-1 beta level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

increased circulating alanine transaminase level

increased circulating aspartate transaminase level

insulin resistance

increased tumor necrosis factor (ligand) superfamily member 11 level

increased tumor necrosis factor receptor superfamily member 11b level

abnormal response/metabolism to endogenous compounds

increased susceptibility to xenobiotic induced morbidity/mortality

Availability

Mouse Genotype

Tnfaip3^m1Apb/Tnfaip3^m1Apb

Tnfaip3^tm1.1Gvl/Tnfaip3^tm1.1Gvl
Tg(Vil1-cre)997Gum/0 (conditional)

Tnfaip3^tm1Homy/Tnfaip3^tm1Homy
Tg(Mx1-cre)1Cgn/? (conditional)

Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/?
Tnfaip3^tm1Homy/Tnfaip3^tm1Homy (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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