|
Symbol Name ID |
Hnf4a
hepatic nuclear factor 4, alpha MGI:109128 |
| Darker colors indicate more annotations |
| Human Phenotypes | Hypophosphatemia |
Increased LDL cholesterol concentration |
Increased VLDL cholesterol concentration |
Hypercholesterolemia |
Hyperlipidemia |
Hypouricemia |
Elevated circulating apolipoprotein A-II concentration |
Elevated circulating apolipoprotein B concentration |
Elevated circulating hepatic transaminase concentration |
Elevated circulating alkaline phosphatase concentration |
Hypoglycemia |
Diabetes mellitus |
Maturity-onset diabetes of the young |
Type II diabetes mellitus |
Insulin resistance |
Metabolic acidosis |
Hyperphosphaturia |
Glycosuria |
Proteinuria |
Aminoaciduria |
| Disease(s) Associated with HNF4A | ||||||||||||||||||||
| familial combined hyperlipidemia | ||||||||||||||||||||
| Fanconi renotubular syndrome 4 | ||||||||||||||||||||
| maturity-onset diabetes of the young type 1 | ||||||||||||||||||||
| type 2 diabetes mellitus |
| Mouse Phenotypes | increased circulating bilirubin level |
decreased circulating insulin level |
increased circulating ketone body level |
decreased circulating HDL cholesterol level |
increased circulating HDL cholesterol level |
decreased circulating cholesterol level |
increased circulating cholesterol level |
decreased circulating free fatty acids level |
decreased circulating triglyceride level |
decreased circulating iron level |
hypokalemia |
impaired glucose tolerance |
improved glucose tolerance |
decreased liver glycogen level |
increased urine glucose level |
abnormal lipid homeostasis |
increased urine phosphate level |
|
| Availability | Mouse Genotype | |||||||||||||||||
| Hnf4atm1.1Mwei/Hnf4atm1.1Mwei | ||||||||||||||||||
| Hnf4atm2.1Mwei/Hnf4atm2.1Mwei | ||||||||||||||||||
| Hnf4atm1b(EUCOMM)Hmgu/Hnf4a+ | ||||||||||||||||||
| Hnf4atm1.1Gonz/Hnf4atm1.1Gonz Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Hnf4atm1.1Gonz/Hnf4atm1.1Gonz Tg(Alb1-cre)1Dlr/0 (conditional) |
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| Hnf4atm1Sad/Hnf4atm1Sad Tg(Alb1-cre)1Khk/0 (conditional) |
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| Hnf4atm1Sad/Hnf4atm1Sad Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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