Symbol
Name
ID

Brca1
breast cancer 1, early onset
MGI:104537

Phenotype annotations related to cellular

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormality of chromosome stability
Disease(s) Associated with BRCA1	Abnormality of chromosome stability
Fanconi anemia

Mouse Phenotypes

cellular phenotype

azoospermia

abnormal centrosome morphology

abnormal chromosome number

abnormal cell adhesion

abnormal cell cycle checkpoint function

abnormal cell death

increased cellular sensitivity to gamma-irradiation

increased apoptosis

abnormal cell migration

decreased T cell proliferation

decreased fibroblast proliferation

increased keratinocyte proliferation

decreased cell proliferation

decreased mammary gland epithelial cell proliferation

increased mammary gland epithelial cell proliferation

early cellular replicative senescence

abnormal double-strand DNA break repair

chromosomal instability

chromosome breakage

Availability

Mouse Genotype

Brca1^tm1Cxd/Brca1^tm1Cxd

Brca1^tm1Rfo/Brca1^tm1Rfo

Brca1^tm1Whl/Brca1^tm1Whl

Brca1^tm2.1Cxd/Brca1^tm2.1Cxd

Brca1^tm2Arge/Brca1^tm2Arge

Brca1^tm2Rjbr/Brca1^tm2Rjbr

Brca1^tm3.1Rjbr/Brca1^tm3.1Rjbr

Brca1^tm5.1Cxd/Brca1^tm5.1Cxd

Brca1^tm1Bhk/Brca1⁺

Brca1^tm1Brn/Brca1^tm1Brn (conditional)

Brca1^tm2Cxd/Brca1^tm2Cxd
Tg(MMTV-cre)4Mam/0 (conditional)

Brca1^tm2Cxd/Brca1^tm2Cxd
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

Brca1^tm2Mak/Brca1^tm2Mak
Tg(Lck-cre)548Jxm/? (conditional)

Brca1^tm1Cxd/Brca1^tm2Cxd
Tg(KRT5-cre)5132Jlj/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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