Symbol
Name
ID

Atp7b
ATPase, Cu++ transporting, beta polypeptide
MGI:103297

Phenotype annotations related to homeostasis/metabolism

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Pedal edema

High nonceruloplasmin-bound serum copper

Increased circulating copper concentration

Hyperbilirubinemia

Hypouricemia

Hypoalbuminemia

Decreased circulating ceruloplasmin concentration

Elevated circulating alanine aminotransferase concentration

Elevated circulating aspartate aminotransferase concentration

Edema

Hepatic steatosis

Hyperphosphaturia

Hypercalciuria

Increased urinary copper concentration

Glycosuria

Proteinuria

Aminoaciduria

Ascites

Chondrocalcinosis

Disease(s) Associated with ATP7B

Wilson disease

Mouse Phenotypes		abnormal circulating bilirubin level	decreased circulating copper level	increased circulating copper level	abnormal copper level	increased brain copper level	increased kidney copper level	abnormal liver copper level	decreased liver copper level	increased liver copper level	abnormal mineral level
Availability	Mouse Genotype	abnormal circulating bilirubin level	decreased circulating copper level	increased circulating copper level	abnormal copper level	increased brain copper level	increased kidney copper level	abnormal liver copper level	decreased liver copper level	increased liver copper level	abnormal mineral level
	Atp7b^m1Btlr/Atp7b^m1Btlr
	Atp7b^tm1Tcg/Atp7b^tm1Tcg
	Atp7b^tx-J/Atp7b^tx-J
	Atp7b^tx/Atp7b^tx		!						!	!

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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