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Symbol Name ID |
Six1
sine oculis-related homeobox 1 MGI:102780 |
| Darker colors indicate more annotations |
| Human Phenotypes | Conductive hearing impairment |
Sensorineural hearing impairment |
| Disease(s) Associated with SIX1 | ||
| autosomal dominant nonsyndromic deafness 23 |
| Mouse Phenotypes | absent stapedial artery |
decreased otic epithelial cell proliferation |
abnormal incus morphology |
absent incus |
abnormal malleus morphology |
abnormal stapes morphology |
absent stapes |
abnormal otic vesicle development |
abnormal inner ear morphology |
abnormal cochlea morphology |
abnormal cochlear hair cell morphology |
decreased cochlear inner hair cell number |
increased cochlear inner hair cell number |
absent scala media |
absent cochlea |
decreased cochlea coiling |
abnormal inner ear canal morphology |
abnormal semicircular canal morphology |
abnormal common crus morphology |
absent lateral semicircular canal |
abnormal crista ampullaris morphology |
absent semicircular canals |
abnormal inner ear vestibule morphology |
small utricle |
abnormal vestibular saccule morphology |
small vestibular saccule |
absent inner ear vestibule |
abnormal endolymphatic duct morphology |
dilated endolymphatic duct |
short endolymphatic duct |
small otic capsule |
absent inner ear |
inner ear hypoplasia |
abnormal middle ear morphology |
abnormal tympanic membrane morphology |
increased or absent threshold for auditory brainstem response |
conductive hearing loss |
unilateral deafness |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
| Six1Cwe/Six1Cwe | |||||||||||||||||||||||||||||||||||||||
| Six1tm1Kwk/Six1tm1Kwk | |||||||||||||||||||||||||||||||||||||||
| Six1tm1Mair/Six1tm1Mair | |||||||||||||||||||||||||||||||||||||||
| Six1tm1Rsd/Six1tm1Rsd | |||||||||||||||||||||||||||||||||||||||
| Six1Cwe/Six1+ | |||||||||||||||||||||||||||||||||||||||
| Six1tm1Mair/Six1+ | |||||||||||||||||||||||||||||||||||||||
| Six1tm1Px/Six1tm1Px Tg(Atoh1-cre/Esr1*)14Fsh/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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