|
Symbol Name ID |
Tsc2
TSC complex subunit 2 MGI:102548 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Adenoma sebaceum |
Gingival fibromatosis |
Retinal hamartoma |
Cardiac rhabdomyoma |
Pulmonary lymphangiomyomatosis |
Adenomatous colonic polyposis |
Renal neoplasm |
Renal cell carcinoma |
Renal angiomyolipoma |
Ungual fibroma |
Subungual fibromas |
Chordoma |
Astrocytoma |
Subependymal giant-cell astrocytoma |
Ependymoma |
Optic nerve glioma |
Subependymal nodules |
Cortical tubers |
Spinal cord tumor |
Medulloblastoma |
Cerebellar medulloblastoma |
Neuroblastoma |
Neoplasm of the lung |
Angiofibromas |
| Disease(s) Associated with TSC2 | ||||||||||||||||||||||||
| lymphangioleiomyomatosis | ||||||||||||||||||||||||
| medulloblastoma | ||||||||||||||||||||||||
| tuberous sclerosis 2 |
| Mouse Phenotypes | neoplasm |
increased skin hamartoma incidence |
increased hepatic hemangioma incidence |
increased uterus leiomyoma incidence |
increased metastatic potential |
increased lung adenoma incidence |
increased adenoma incidence |
increased renal cystadenoma incidence |
increased hamartoma incidence |
increased renal carcinoma incidence |
increased extremity angiosarcoma incidence |
increased lung tumor incidence |
increased kidney tumor incidence |
increased tumor incidence |
|
| Availability | Mouse Genotype | ||||||||||||||
| Tsc2tm1.1Kido/Tsc2+ | |||||||||||||||
| Tsc2tm1.2Mjg/Tsc2+ | |||||||||||||||
| Tsc2tm1Djk/Tsc2+ | ! | ||||||||||||||
| Tsc2tm1Tno/Tsc2+ | |||||||||||||||
| Tsc2tm2.2Djk/Tsc2+ | |||||||||||||||
| Tg(CMV-Tsc2*)1Arbi/0 | |||||||||||||||
| Amhr2tm3(cre)Bhr/Amhr2+ Tsc2tm1.1Mjg/Tsc2tm1.1Mjg (conditional) |
* | ||||||||||||||
| Tsc2tm1.1Mjg/Tsc2tm1.1Mjg Pgrtm2(cre)Lyd/Pgr+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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