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Symbol Name ID |
Notch1
notch 1 MGI:97363 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Cataract |
Developmental cataract |
Optic atrophy |
Hypertelorism |
Microphthalmia |
Strabismus |
Esotropia |
Visual impairment |
| Disease(s) Associated with NOTCH1 | ||||||||
| Adams-Oliver syndrome |
| Mouse Phenotypes | vision/eye phenotype |
abnormal retina blood vessel morphology |
cornea vascularization |
Meibomian gland degeneration |
lacrimal gland degeneration |
decreased conjunctiva goblet cell number |
abnormal cornea morphology |
cornea deposits |
dry eyes |
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| Availability | Mouse Genotype | |||||||||
| Notch1tm1Grid/Notch1+ | ||||||||||
| Notch1tm2Rko/Notch1tm2Rko Tg(KRT14-rtTA)F42Efu/0 Tg(tetO-cre)1Jaw/0 (conditional) |
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| Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Shhtm2(cre/ERT2)Cjt/Shh+ (conditional) |
* | |||||||||
| Notch1tm2Rko/Notch1tm3(cre)Rko (conditional) | ||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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