Symbol Name ID |
Lrp2
low density lipoprotein receptor-related protein 2 MGI:95794 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Cataract |
Hypoplasia of the iris |
Iris coloboma |
Retinal detachment |
Retinal dystrophy |
Hypertelorism |
Proptosis |
Myopia |
High myopia |
Progressive visual loss |
Disease(s) Associated with LRP2 | ||||||||||
Donnai-Barrow syndrome |
Mouse Phenotypes | vision/eye phenotype |
increased retina apoptosis |
decreased retina ganglion cell number |
abnormal retina bipolar cell morphology |
abnormal optic nerve morphology |
abnormal retina pigment epithelium morphology |
abnormal retina pigmentation |
abnormal eye morphology |
abnormal placement of pupils |
abnormal lens morphology |
ocular hypotelorism |
macrophthalmia |
microphthalmia |
abnormal posterior eye segment morphology |
thin retina inner nuclear layer |
thin retina inner plexiform layer |
thin retina outer nuclear layer |
decreased total retina thickness |
abnormal sclera morphology |
sclera thinning |
anophthalmia |
abnormal intraocular pressure |
high myopia |
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Availability | Mouse Genotype | |||||||||||||||||||||||
Lrp227SH/Lrp227SH | ||||||||||||||||||||||||
Lrp2b2b2671Clo/Lrp2b2b2671Clo | ||||||||||||||||||||||||
Lrp2tm1Her/Lrp2tm1Her | ||||||||||||||||||||||||
H2az2Tg(Wnt1-cre)11Rth/H2az2+ Lrp2tm1Tew/Lrp2tm1Tew (conditional) |
* | |||||||||||||||||||||||
Lrp2tm1Tew/Lrp2tm1Tew Tg(GFAP-cre)25Mes/0 (conditional) |
* | |||||||||||||||||||||||
Foxg1tm1(cre)Skm/Foxg1+ Lrp2tm1Tew/Lrp2tm1Tew (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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