Symbol
Name
ID

Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
MGI:107560

Phenotype annotations related to vision/eye

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Attenuation of retinal blood vessels	Macular degeneration	Bone spicule pigmentation of the retina	Rod-cone dystrophy	Nyctalopia	Photophobia	Reduced visual acuity	Blindness	Peripheral visual field loss	Progressive visual loss	Epiphora
Disease(s) Associated with SEMA4A	Attenuation of retinal blood vessels	Macular degeneration	Bone spicule pigmentation of the retina	Rod-cone dystrophy	Nyctalopia	Photophobia	Reduced visual acuity	Blindness	Peripheral visual field loss	Progressive visual loss	Epiphora
cone-rod dystrophy 10
retinitis pigmentosa 35

Mouse Phenotypes

vision/eye phenotype

increased retina apoptosis

decreased retina photoreceptor cell number

abnormal photoreceptor outer segment morphology

absent photoreceptor outer segment

abnormal retina cone cell outer segment morphology

abnormal retina rod cell outer segment morphology

abnormal retina pigment epithelium morphology

decreased eye pigmentation

abnormal eye morphology

thin retina inner nuclear layer

thin retina inner plexiform layer

thin retina outer nuclear layer

retina degeneration

abnormal eye physiology

abnormal eye electrophysiology

Availability

Mouse Genotype

Sema4a^{Gt(OST393408)Lex}/Sema4a^{Gt(OST393408)Lex}

Sema4a^tm1.1Akum/Sema4a^tm1.1Akum

Sema4a^tm1Kik/Sema4a^tm1Kik

Sema4a^tm2.1Akum/Sema4a^tm2.1Akum

Sema4a^tm3.1Akum/Sema4a^tm3.1Akum

Sema4a^tm4.1Akum/Sema4a^tm4.1Akum

Sema4a^tm2.1Akum/Sema4a^tm3.1Akum

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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