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Symbol
Name
ID

Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
MGI:98354

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes

Micrognathia

Macrocephaly

Short neck

Clinodactyly of the 5th finger

Brachydactyly

Radioulnar synostosis

Cubitus valgus

Joint hypermobility

Delayed skeletal maturation

Enlarged thorax

Abnormal sternum morphology

Pectus carinatum

Pectus excavatum

Pectus excavatum of inferior sternum

Scoliosis

Osteopenia

Disease(s) Associated with SOS1

Noonan syndrome

Noonan syndrome 4

Mouse Phenotypes		decreased cranium height	abnormal frontal bone morphology
Availability	Mouse Genotype	decreased cranium height	abnormal frontal bone morphology
	Sos1^tm1.2Rak/Sos1^tm1.2Rak
	Sos1^tm1.2Rak/Sos1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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