Symbol
Name
ID

Ihh
Indian hedgehog
MGI:96533

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes

Sagittal craniosynostosis

Relative macrocephaly

Radial bowing

Genu varum

Radial deviation of the 2nd finger

Radial deviation of the 3rd finger

Radial deviation of the 4th finger

Clinodactyly of the 5th finger

Absent distal interphalangeal creases

Single interphalangeal crease of fifth finger

Short distal phalanx of finger

Distal symphalangism of hands

Cone-shaped epiphysis of the 1st metacarpal

Cone-shaped epiphyses of the phalanges of the hand

Thin proximal phalanges with broad epiphyses of the hand

Aplasia/Hypoplasia of the middle phalanges of the hand

Short middle phalanx of finger

Short proximal phalanx of thumb

Short proximal phalanx of finger

Symphalangism affecting the phalanges of the hand

Short thumb

Proportionate shortening of all digits

Small finger

Short proximal phalanx of hallux

Short hallux

Aplasia/Hypoplasia of the middle phalanges of the toes

Toe syndactyly

2-3 toe syndactyly

Brachydactyly

Cutaneous syndactyly

3-4 finger syndactyly

Enlargement of the distal femoral epiphysis

Cone-shaped capital femoral epiphysis

Broad metacarpal epiphyses

Cone-shaped metacarpal epiphyses

Dysplasia of the femoral head

Coxa vara

Short femoral neck

Short femur

Fibular overgrowth

Flattened metatarsal heads

Short tibia

Short foot

Hypoplasia of the radius

Hypoplasia of the ulna

Short metacarpal

Broad metacarpals

Slender metacarpals

Short humerus

Short palm

Delayed ossification of carpal bones

Limb undergrowth

Micromelia

Cone-shaped epiphysis

Flared iliac wing

Hypoplastic iliac wing

Short ribs

Cupped ribs

Pectus carinatum

Pectus excavatum

Narrow chest

Lumbar hyperlordosis

Scoliosis

Ovoid vertebral bodies

Disease(s) Associated with IHH

acrocapitofemoral dysplasia

brachydactyly type A1

syndactyly type 1

Mouse Phenotypes

decreased chondrocyte proliferation

abnormal basicranium morphology

short mandible

abnormal palatine bone morphology

domed cranium

fused carpal bones

abnormal phalanx morphology

brachyphalangia

abnormal humerus morphology

short humerus

short ulna

short fibula

short tibia

abnormal skeleton morphology

abnormal appendicular skeleton morphology

abnormal long bone morphology

abnormal long bone epiphyseal plate proliferative zone

decreased width of hypertrophic chondrocyte zone

decreased long bone epiphyseal plate size

disorganized long bone epiphyseal plate

decreased length of long bones

short scapula

abnormal sternum morphology

abnormal axial skeleton morphology

abnormal rib morphology

short ribs

abnormal vertebrae morphology

abnormal bone structure

absent compact bone

decreased osteoblast cell number

abnormal trabecular bone morphology

abnormal cartilage morphology

abnormal cartilage development

abnormal synchondrosis

abnormal chondrocyte differentiation

abnormal joint morphology

abnormal skeleton development

chondrodystrophy

abnormal bone ossification

abnormal bone mineralization

delayed endochondral bone ossification

Availability

Mouse Genotype

Ihh^tm1.1Dcha/Ihh^tm1.1Dcha

Ihh^tm1Amc/Ihh^tm1Amc

Ihh^tm1.1Dcha/Ihh⁺

Ihh^tm1Amc/Ihh⁺

Ihh^tm1Blan/Ihh^tm1Blan
Tg(Col2a1-cre)10Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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