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Symbol
Name
ID

Sfrp4
secreted frizzled-related protein 4
MGI:892010

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes	Metaphyseal dysplasia	Metaphyseal chondrodysplasia
Disease(s) Associated with SFRP4	Metaphyseal dysplasia	Metaphyseal chondrodysplasia
metaphyseal dysplasia

Mouse Phenotypes

increased osteoclast cell number

decreased femur compact bone thickness

abnormal long bone metaphysis morphology

increased diameter of long bones

increased trabecular bone volume

decreased compact bone mass

decreased compact bone thickness

decreased susceptibility to osteoporosis

increased bone trabecula number

decreased bone trabecular spacing

increased trabecular bone connectivity density

increased trabecular bone mass

abnormal bone ossification

abnormal bone mineralization

increased bone ossification

abnormal bone remodeling

increased bone resorption

decreased bone strength

Availability

Mouse Genotype

Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan

Sfrp4^tm1.1Lex/Sfrp4^tm1.1Lex

Sfrp4^tm1Maki/Sfrp4^tm1Maki

Sfrp4^tm1.1Blan/Sfrp4⁺

Sfrp4^tm1.1Lex/Sfrp4⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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