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Symbol
Name
ID

Sqstm1
sequestosome 1
MGI:107931

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Scapular winging	Bone pain	Fractures of the long bones	Patchy osteosclerosis	Osteolysis	Osteosarcoma
Disease(s) Associated with SQSTM1	Scapular winging	Bone pain	Fractures of the long bones	Patchy osteosclerosis	Osteolysis	Osteosarcoma
distal myopathy with rimmed vacuoles
Paget's disease of bone 3

Mouse Phenotypes

skeleton phenotype

abnormal osteoclast differentiation

abnormal osteoblast physiology

decreased osteoclast cell number

increased osteoclast cell number

abnormal osteoclast morphology

abnormal osteoclast physiology

lordokyphosis

abnormal bone structure

increased bone mineral density of femur

increased bone volume

abnormal compact bone morphology

abnormal trabecular bone morphology

increased bone trabecula number

decreased bone trabecular spacing

abnormal bone ossification

abnormal bone mineralization

abnormal bone remodeling

Availability

Mouse Genotype

Sqstm1^tm1.1Sral/Sqstm1^tm1.1Sral

Sqstm1^tm1Hwl/Sqstm1^tm1Hwl

Sqstm1^tm1Jjw/Sqstm1^tm1Jjw

*

Sqstm1^tm1Jmos/Sqstm1^tm1Jmos

Sqstm1^tm1Keta/Sqstm1^tm1Keta

Sqstm1^tm1.1Sral/Sqstm1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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