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Symbol Name ID |
Pten
phosphatase and tensin homolog MGI:109583 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Mouse Phenotypes | respiratory system phenotype |
abnormal lung vasculature morphology |
increased lung endothelial cell proliferation |
increased mesenchymal cell proliferation involved in lung development |
pulmonary hyperplasia |
abnormal alveolar macrophage morphology |
pulmonary edema |
respiratory acidosis |
lung inflammation |
increased lung adenocarcinoma incidence |
increased lung squamous cell carcinoma incidence |
abnormal lung morphology |
abnormal lung development |
abnormal lung saccule morphology |
small lung saccule |
abnormal lung-associated mesenchyme development |
abnormal lung epithelium morphology |
increased bronchioalveolar stem cell number |
increased club cell number |
bronchiolar epithelial hyperplasia |
bronchial epithelial hyperplasia |
abnormal pulmonary alveolus epithelial cell morphology |
abnormal type I pneumocyte morphology |
abnormal type II pneumocyte morphology |
decreased alveolar lamellar body number |
abnormal alveolocapillary membrane morphology |
abnormal respiratory epithelium morphology |
respiratory distress |
respiratory failure |
decreased surfactant secretion |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
| Ptentm1Hwu/Ptentm1Hwu Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Tg(Scgb1a1-cre)1Tauc/0 (conditional) |
* | ||||||||||||||||||||||||||||||
| Ptentm1Hwu/Ptentm1Hwu Tg(Nkx2-1-cre)2Sand/0 (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ (conditional) |
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| Ptentm2Mak/Ptentm2Mak Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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