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Symbol Name ID |
Dicer1
dicer 1, ribonuclease type III MGI:2177178 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Renal cell carcinoma |
| Disease(s) Associated with DICER1 | |
| colorectal cancer | |
| multinodular goiter |
| Mouse Phenotypes | renal/urinary system phenotype |
abnormal renal tubule epithelial cell primary cilium morphology |
increased kidney apoptosis |
increased kidney cell proliferation |
kidney cortex cyst |
decreased urine osmolality |
increased urine protein level |
albuminuria |
decreased susceptibility to kidney reperfusion injury |
abnormal kidney morphology |
decreased kidney collecting duct number |
abnormal renal corpuscle morphology |
dilated renal glomerular capsule |
abnormal renal glomerulus morphology |
renal interstitial fibrosis |
decreased kidney weight |
dilated renal tubule |
pale kidney |
decreased renal glomerular filtration rate |
isosthenuria |
polyuria |
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| Availability | Mouse Genotype | |||||||||||||||||||||
| Dicer1tm1Bdh/Dicer1tm1Bdh Hprt1tm1(Pck1-cre)Vhh/Y (conditional) |
* | |||||||||||||||||||||
| Dicer1tm1Smr/Dicer1tm1Smr Pax8tm1.1(cre)Mbu/Pax8+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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