Symbol
Name
ID

Thrb
thyroid hormone receptor beta
MGI:98743

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Delayed speech and language development	Attention deficit hyperactivity disorder
Disease(s) Associated with THRB	Delayed speech and language development	Attention deficit hyperactivity disorder
thyroid hormone resistance syndrome

Mouse Phenotypes

audiogenic seizures

increased thyrotroph cell number

enlarged pituitary gland

increased pituitary adenoma incidence

abnormal pituitary gland physiology

decreased cochlear outer hair cell number

cochlear outer hair cell degeneration

short cochlear outer hair cells

cochlear hair cell degeneration

abnormal cochlear inner hair cell physiology

abnormal cochlear outer hair cell physiology

decreased cochlear microphonics

decreased cochlear outer hair cell electromotility

abnormal cochlear nerve compound action potential

abnormal cerebellar Purkinje cell layer

abnormal Purkinje cell morphology

decreased Purkinje cell number

thin cerebellar molecular layer

small cerebellum

abnormal retina cone cell morphology

impaired synaptic plasticity

decreased excitatory postsynaptic current amplitude

reduced long-term potentiation

Availability

Mouse Genotype

Thrb^tm1.1Syc/Thrb^tm1.1Syc

Thrb^tm1Df/Thrb^tm1Df

Thrb^tm1Ehs/Thrb^tm1Ehs

Thrb^tm2Df/Thrb^tm2Df

Thrb^tm2Few/Thrb^tm2Few

Thrb^tm3Few/Thrb^tm3Few

Thrb^tm4Few/Thrb^tm4Few

Thrb^tm1.1Syc/Thrb⁺

Thrb^tm2Few/Thrb⁺

Thrb^tm1Df/Thrb^tm1Mkni
Tg(Pres-cre)1Jnz/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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