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Symbol Name ID |
Sox4
SRY (sex determining region Y)-box 4 MGI:98366 |
| Darker colors indicate more annotations |
| Human Phenotypes | Microcephaly |
Spastic tetraparesis |
Cerebellar atrophy |
Delayed speech and language development |
Intellectual disability |
Global developmental delay |
Delayed ability to walk |
| Disease(s) Associated with SOX4 | |||||||
| Coffin-Siris syndrome 10 |
| Mouse Phenotypes | abnormal axon fasciculation |
abnormal neural tube morphology |
abnormal neural tube closure |
abnormal sympathetic ganglion morphology |
abnormal brain morphology |
abnormal hindbrain development |
decreased brain size |
abnormal nervous system development |
decreased amacrine cell number |
decreased retina ganglion cell number |
abnormal retina bipolar cell morphology |
optic nerve hypoplasia |
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| Availability | Mouse Genotype | ||||||||||||
| Sox4em1(IMPC)Mbp/Sox4em1(IMPC)Mbp | |||||||||||||
| Sox4em1(IMPC)Mbp/Sox4+ | |||||||||||||
| Sox4tm1Vlf/Sox4tm1Vlf Tg(Dbh-icre)1Gsc/0 (conditional) |
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| Sox4tm1Vlf/Sox4tm1Vlf Tg(Six3-cre)69Frty/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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