Symbol
Name
ID

Sox11
SRY (sex determining region Y)-box 11
MGI:98359

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Microcephaly	Decreased response to growth hormone stimulation test	Intellectual disability, mild
Disease(s) Associated with SOX11
Coffin-Siris syndrome 9

Mouse Phenotypes

increased neuron apoptosis

abnormal neuron differentiation

abnormal axon fasciculation

abnormal neuronal precursor proliferation

abnormal sympathetic ganglion morphology

abnormal cortical ventricular zone morphology

decreased brain size

abnormal hippocampus morphology

abnormal hippocampus CA2 region morphology

abnormal hippocampus CA3 region morphology

abnormal dentate gyrus morphology

small hippocampus

abnormal cerebral cortex morphology

thin cerebral cortex

abnormal olfactory bulb morphology

small olfactory bulb

abnormal cerebellum morphology

small cerebellum

abnormal nervous system development

abnormal embryonic/fetal subventricular zone morphology

decreased amacrine cell number

decreased retina ganglion cell number

abnormal retina bipolar cell morphology

optic nerve hypoplasia

Availability

Mouse Genotype

Sox11^tm1.2Llei/Sox11^tm1.2Llei

Sox11^tm1Weg/Sox11^tm1Weg

Sox11^tm1.1Gan/Sox11^tm1.1Gan
Tg(Six3-cre)69Frty/0 (conditional)

Sox11^tm1.1Llei/Sox11^tm1.1Llei
Tg(Nes-cre/ERT2)73Lfp/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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