Symbol Name ID |
Plp1
proteolipid protein (myelin) 1 MGI:97623 |
* | Aspects of the system are reported to show a normal phenotype. |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Microcephaly |
Dysphagia |
Abnormality of visual evoked potentials |
Spasticity |
Lower limb spasticity |
Spastic paraplegia |
Progressive spastic quadriplegia |
Spastic gait |
Reduction of oligodendroglia |
Abnormal CNS myelination |
Cerebral dysmyelination |
CNS hypomyelination |
Sudanophilic leukodystrophy |
Cerebral cortical atrophy |
Thin corpus callosum |
Abnormal cerebellum morphology |
Cerebellar vermis atrophy |
Global brain atrophy |
Degeneration of the lateral corticospinal tracts |
Spinocerebellar tract degeneration |
Ataxia |
Dysmetria |
Abnormality of extrapyramidal motor function |
Choreoathetosis |
Tremor |
Intention tremor |
Head titubation |
Abnormal pyramidal sign |
Babinski sign |
Abnormality of speech or vocalization |
Delayed speech and language development |
Dysarthria |
Scanning speech |
Depression |
Atypical behavior |
Apathy |
Cognitive impairment |
Mental deterioration |
Psychomotor deterioration |
Intellectual disability |
Intellectual disability, mild |
Abnormality of movement |
Hyperreflexia |
Hyporeflexia |
Dystonia |
Writer's cramp |
Generalized dystonia |
Gait disturbance |
Broad-based gait |
Inability to walk |
Loss of ambulation |
Developmental regression |
Global developmental delay |
Peripheral neuropathy |
Sensory neuropathy |
Seizure |
Disease(s) Associated with PLP1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
hereditary spastic paraplegia 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Pelizaeus-Merzbacher disease |
Mouse Phenotypes | nervous system phenotype |
seizures |
environmentally induced seizures |
tonic-clonic seizures |
abnormal oligodendrocyte apoptosis |
abnormal microglial cell morphology |
microgliosis |
abnormal brain morphology |
abnormal brain development |
abnormal brain white matter morphology |
abnormal cerebellum white matter morphology |
abnormal optic tract morphology |
abnormal hippocampal fimbria morphology |
abnormal cerebellum morphology |
abnormal cerebellar granule layer morphology |
abnormal glial cell morphology |
abnormal CNS glial cell morphology |
abnormal astrocyte morphology |
astrocytosis |
abnormal oligodendrocyte morphology |
decreased oligodendrocyte number |
increased oligodendrocyte number |
gliosis |
abnormal axon morphology |
abnormal myelin sheath morphology |
decreased myelin sheath thickness |
tomacula |
abnormal optic nerve morphology |
neurodegeneration |
axon degeneration |
axonal spheroids |
abnormal astrocyte physiology |
abnormal myelination |
demyelination |
dysmyelination |
abnormal nerve conduction |
decreased nerve conduction velocity |
abnormal axonal transport |
|
Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
Plp1jp-msd/Plp1jp-msd | |||||||||||||||||||||||||||||||||||||||
Plp1jp-rsh/Plp1jp-rsh | |||||||||||||||||||||||||||||||||||||||
Plp1tm1Wst/Plp1tm1Wst | |||||||||||||||||||||||||||||||||||||||
Plp1tm2Wst/Plp1tm2Wst | |||||||||||||||||||||||||||||||||||||||
Plp1tm3Wst/Plp1tm3Wst | |||||||||||||||||||||||||||||||||||||||
Tg(Plp)66Kan/Tg(Plp)66Kan | |||||||||||||||||||||||||||||||||||||||
Tg(Plp)72Kan/Tg(Plp)72Kan | |||||||||||||||||||||||||||||||||||||||
Plp1jp-rsh/Plp1+ | |||||||||||||||||||||||||||||||||||||||
Plp1jp/Plp1+ | |||||||||||||||||||||||||||||||||||||||
Plp1tm1Kan/Plp1+ | |||||||||||||||||||||||||||||||||||||||
Plp1tm1Wst/Plp1+ | |||||||||||||||||||||||||||||||||||||||
Plp1tm2Wst/Plp1+ | |||||||||||||||||||||||||||||||||||||||
Plp1jp-4J/Y | |||||||||||||||||||||||||||||||||||||||
Plp1jp-msd/Y | |||||||||||||||||||||||||||||||||||||||
Plp1jp-rsh/Y | ! | ! | ! | ! | |||||||||||||||||||||||||||||||||||
Plp1jp/Y | |||||||||||||||||||||||||||||||||||||||
Plp1tm1.1Blyg/Y | * | ||||||||||||||||||||||||||||||||||||||
Plp1tm1.1Gow/Y | |||||||||||||||||||||||||||||||||||||||
Plp1tm1Frca/Y | |||||||||||||||||||||||||||||||||||||||
Plp1tm1Gow/Y | |||||||||||||||||||||||||||||||||||||||
Plp1tm1Kan/Y | |||||||||||||||||||||||||||||||||||||||
Tg(Plp)66Kan/0 | |||||||||||||||||||||||||||||||||||||||
Plp1tm1Kan/? | |||||||||||||||||||||||||||||||||||||||
Plp1tm1c(EUCOMM)Wtsi/Y Cnptm1(cre)Kan/Cnp+ (conditional) |
|||||||||||||||||||||||||||||||||||||||
Plp1tm1c(EUCOMM)Wtsi/Y Neurod6tm1(cre)Kan/Neurod6+ (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/21/2024 MGI 6.23 |
|
|