|
Symbol Name ID |
Notch1
notch 1 MGI:97363 |
| Darker colors indicate more annotations |
| Human Phenotypes | Microcephaly |
Encephalocele |
Lateral ventricle dilatation |
Hydrocephalus |
Ventriculomegaly |
Pachygyria |
Polymicrogyria |
Cortical dysplasia |
Hypoplasia of the corpus callosum |
Periventricular leukomalacia |
Cerebral atrophy |
Porencephalic cyst |
Cerebellar hypoplasia |
Retrocerebellar cyst |
Hemiparesis |
EEG abnormality |
Delayed speech and language development |
Intellectual disability |
Intellectual disability, mild |
Global developmental delay |
Severe global developmental delay |
Delayed gross motor development |
Seizure |
| Disease(s) Associated with NOTCH1 | |||||||||||||||||||||||
| Adams-Oliver syndrome |
| Mouse Phenotypes | abnormal embryonic neuroepithelium morphology |
kinked neural tube |
neural tube degeneration |
increased cochlear inner hair cell number |
increased cochlear outer hair cell number |
abnormal nervous system development |
increased neuron number |
abnormal trigeminal ganglion morphology |
|
| Availability | Mouse Genotype | ||||||||
| Notch1sot/Notch1sot | |||||||||
| Notch1tm1Con/Notch1tm1Con | |||||||||
| Notch1tm1Rko/Notch1tm1Rko | |||||||||
| Notch1tm1Grid/Notch1+ | |||||||||
| Notch1tm2Pst/Notch1tm2.1Pst | |||||||||
| Notch1tm1Agt/Notch1tm1Agt Tg(Tek-cre)1Ywa/0 (conditional) |
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| Notch1tm1Agt/Notch1tm1Agt Tg(Tek-cre)12Flv/0 (conditional) |
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| Notch1tm2Rko/Notch1tm2Rko Tg(Nes-cre)1Kln/0 (conditional) |
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| Notch1tm1Grid/Notch1tm2Rko Foxg1tm1(cre)Skm/Foxg1+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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