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Symbol
Name
ID

Lrp1
low density lipoprotein receptor-related protein 1
MGI:96828

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Intellectual disability
Disease(s) Associated with LRP1	Intellectual disability
keratosis pilaris atrophicans

Mouse Phenotypes		nervous system phenotype	decreased brain cholesterol level	brain inflammation	abnormal forebrain morphology	decreased dendritic spine density	abnormal synapse morphology	neurodegeneration	abnormal nervous system physiology	reduced long-term potentiation
Availability	Mouse Genotype	nervous system phenotype	decreased brain cholesterol level	brain inflammation	abnormal forebrain morphology	decreased dendritic spine density	abnormal synapse morphology	neurodegeneration	abnormal nervous system physiology	reduced long-term potentiation
	Lrp1^{tm1.1(KOMP)Wtsi}/Lrp1^{tm1.1(KOMP)Wtsi}
	Lrp1^tm2Her/Lrp1^tm2Her Tg(Syn1-cre)671Jxm/0 (conditional)	*
	Lrp1^tm2Her/Lrp1^tm2Her Tg(Camk2a-cre)T29-1Stl/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23