|
Symbol Name ID |
Kras
Kirsten rat sarcoma viral oncogene homolog MGI:96680 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Dandy-Walker malformation |
Cerebral arteriovenous malformation |
Abnormal cerebral vascular morphology |
Transient ischemic attack |
Aganglionic megacolon |
Anorexia |
Pituitary adenoma |
Pineal cyst |
Cerebral calcification |
Abnormal nervous system morphology |
Glioblastoma multiforme |
Peripheral axonal neuropathy |
Hydrocephalus |
Ventriculomegaly |
Cerebral cortical atrophy |
Aplasia/Hypoplasia of the corpus callosum |
Agenesis of corpus callosum |
Absent septum pellucidum |
Hemimegalencephaly |
Porencephalic cyst |
Aplasia/Hypoplasia of the cerebellum |
Chiari type I malformation |
Arachnoid cyst |
Spinal cord compression |
Benign neoplasm of the central nervous system |
Neuroblastoma |
Abnormal pyramidal sign |
Hemiplegia/hemiparesis |
EEG abnormality |
Increased intracranial pressure |
Abnormality of speech or vocalization |
Dysarthria |
Dysgraphia |
Depression |
Irritability |
Disturbed sensory perception |
Anxiety |
Hallucinations |
Atypical behavior |
Hyperactivity |
Attention deficit hyperactivity disorder |
Memory impairment |
Intellectual disability |
Hyperreflexia |
Reduced tendon reflexes |
Dyskinesia |
Gait disturbance |
Migraine |
Developmental regression |
Neurodevelopmental delay |
Global developmental delay |
Specific learning disability |
Seizure |
Paresthesia |
| Disease(s) Associated with KRAS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| arteriovenous malformations of the brain | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| cardiofaciocutaneous syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| cardiofaciocutaneous syndrome 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| linear nevus sebaceous syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lynch syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Noonan syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Noonan syndrome 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| oculoectodermal syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | nervous system phenotype |
abnormal brain vasculature morphology |
intracranial hemorrhage |
increased neuron apoptosis |
increased embryonic neuroepithelium apoptosis |
abnormal embryonic neuroepithelium morphology |
abnormal brain development |
abnormal hippocampus morphology |
abnormal CNS glial cell morphology |
abnormal astrocyte morphology |
|
| Availability | Mouse Genotype | ||||||||||
| Krastm1Mok/Krastm1Mok | |||||||||||
| Krastm4.1Tyj/Kras+ | |||||||||||
| Krastm4Tyj/Kras+ Tg(Fabp7-cre,-lacZ)3Gtm/0 (conditional) |
* | ||||||||||
| Krastm4Tyj/Kras+ Tg(Cdh5-cre/ERT2)1Rha/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Slco1c1-icre/ERT2)1Mrks/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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