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Symbol Name ID |
Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1 MGI:96654 |
| Darker colors indicate more annotations |
| Human Phenotypes | Spastic gait |
Episodic ataxia |
Incoordination |
Slurred speech |
Tremor |
Babinski sign |
Dysarthria |
Hyperreflexia |
Myokymia |
Headache |
| Disease(s) Associated with KCNA1 | ||||||||||
| episodic ataxia type 1 |
| Mouse Phenotypes | increased susceptibility to pharmacologically induced seizures |
seizures |
convulsive seizures |
myoclonus |
tonic-clonic seizures |
abnormal brain morphology |
abnormal brain development |
abnormal brain size |
increased brain weight |
increased brain size |
enlarged hippocampus |
abnormal cerebral cortex morphology |
abnormal astrocyte morphology |
abnormal nervous system electrophysiology |
abnormal action potential |
abnormal brain wave pattern |
decreased nerve fiber response threshold |
abnormal CNS synaptic transmission |
abnormal inhibitory postsynaptic currents |
abnormal PNS synaptic transmission |
abnormal paired-pulse facilitation |
decreased paired-pulse ratio |
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| Availability | Mouse Genotype | ||||||||||||||||||||||
| Kcna1mceph/Kcna1mceph | |||||||||||||||||||||||
| Kcna1tm1Tem/Kcna1tm1Tem | |||||||||||||||||||||||
| Kcna1tm1Jmay/Kcna1+ | |||||||||||||||||||||||
| Kcna1tm1Tem/Kcna1+ | |||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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