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Symbol
Name
ID
Igf1
insulin-like growth factor 1
MGI:96432
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Anorexia
Abnormality of the nervous system
Gliosis
Cerebellar atrophy
Neuronal loss in central nervous system
Gait ataxia
Bradykinesia
Chorea
Depression
Personality changes
Polydipsia
Polyphagia
Dementia
Hyperreflexia
Seizure
Disease(s) Associated with IGF1
Huntington's disease
myopia
pancreatic cancer
type 1 diabetes mellitus

Mouse Phenotypes
increased neuron apoptosis
abnormal brain morphology
abnormal olfactory bulb layer morphology
abnormal olfactory bulb external plexiform layer morphology
abnormal olfactory bulb mitral cell layer morphology
abnormal mitral cell morphology
abnormal sensory neuron innervation pattern
decreased motor neuron number
abnormal cochlear ganglion morphology
cochlear ganglion degeneration
small cochlear ganglion
abnormal cochlear nerve morphology
abnormal nervous system physiology
abnormal myelination
Availability Mouse Genotype
Igf1tm1Arge/Igf1tm1Arge
Igf1tm1Ts/Igf1tm1Ts
Igf1tm1Arge/Igf1+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory