Symbol
Name
ID

Hesx1
homeobox gene expressed in ES cells
MGI:96071

Phenotype annotations related to nervous system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Anosmia

Anterior pituitary hypoplasia

Optic nerve hypoplasia

Septo-optic dysplasia

Agenesis of corpus callosum

Absent septum pellucidum

Aplasia/Hypoplasia of the cerebellum

Hemiplegia/hemiparesis

Autism

Polydipsia

Intellectual disability

Sleep abnormality

Global developmental delay

Seizure

Disease(s) Associated with HESX1

septooptic dysplasia

Mouse Phenotypes

small vomeronasal organ

decreased embryonic neuroepithelium thickness

abnormal pituitary gland morphology

abnormal adenohypophysis morphology

abnormal Rathke's pouch development

absent Rathke's pouch

bifurcated Rathke's pouch

ectopic adenohypophysis

small adenohypophysis

absent pituitary infundibular stalk

ectopic pituitary gland

abnormal forebrain development

abnormal telencephalon development

small embryonic telencephalon

abnormal midbrain-hindbrain boundary development

decreased forebrain size

abnormal dorsal telencephalic commissure morphology

abnormal corpus callosum morphology

absent corpus callosum

absent hippocampal commissure

abnormal anterior commissure morphology

absent anterior commissure

abnormal forebrain morphology

abnormal hypothalamus morphology

abnormal telencephalon morphology

olfactory bulb hypoplasia

abnormal septum pellucidum morphology

exencephaly

Availability

Mouse Genotype

Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb

Hesx1^tm1Icar/Hesx1^tm1Icar

Hesx1^tm2Jpmb/Hesx1^tm2Jpmb

Hesx1^tm3Jpmb/Hesx1^tm3Jpmb

Hesx1^tm4.1Jpmb/Hesx1^tm4.1Jpmb

Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar

Hesx1^tm1Icar/Hesx1⁺

Hesx1^tm1Icar/Hesx1^tm2Jpmb

Hesx1^tm1Icar/Hesx1^tm3Jpmb

Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}/Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}
Tmem163^{Tg(ACTB-cre)2Mrt}/0 (conditional)

Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}/Gt(ROSA)26Sor⁺
Tmem163^{Tg(ACTB-cre)2Mrt}/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13