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Symbol Name ID |
Gli3
GLI-Kruppel family member GLI3 MGI:95729 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased response to growth hormone stimulation test |
Panhypopituitarism |
Hydrocephalus |
Ventriculomegaly |
Agenesis of corpus callosum |
Hypoplasia of the corpus callosum |
Hypothalamic hamartoma |
Cerebellar hypoplasia |
Holoprosencephaly |
Delayed speech and language development |
Intellectual disability |
Intellectual disability, mild |
Global developmental delay |
Seizure |
| Disease(s) Associated with GLI3 | ||||||||||||||
| Greig cephalopolysyndactyly syndrome | ||||||||||||||
| Pallister-Hall syndrome | ||||||||||||||
| polydactyly |
| Mouse Phenotypes | nervous system phenotype |
abnormal radial glial cell morphology |
abnormal neuronal migration |
abnormal melanoblast morphology |
incomplete rostral neuropore closure |
abnormal rhombomere morphology |
absent pineal gland |
abnormal brain morphology |
abnormal hippocampus development |
abnormal telencephalon development |
abnormal cerebellar foliation |
reduced cerebellar foliation |
abnormal midbrain-hindbrain boundary morphology |
hydrocephaly |
increased forebrain size |
enlarged cerebral aqueduct |
absent corpus callosum |
absent hippocampal commissure |
absent anterior commissure |
abnormal midbrain morphology |
abnormal tectum morphology |
abnormal inferior colliculus morphology |
abnormal superior colliculus morphology |
enlarged tectum |
abnormal hypothalamus morphology |
abnormal thalamus morphology |
abnormal hippocampal fornix morphology |
abnormal hippocampus pyramidal cell layer |
abnormal cerebral hemisphere morphology |
abnormal cerebral cortex morphology |
abnormal stratification in cerebral cortex |
thin cerebral cortex |
absent olfactory bulb |
abnormal hindbrain morphology |
abnormal cerebellum morphology |
abnormal cerebellar Purkinje cell layer |
exencephaly |
abnormal olfactory nerve morphology |
absent optic nerve |
encephalomeningocele |
spongiform encephalopathy |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||
| Gli3Mos1/Gli3Mos1 | ||||||||||||||||||||||||||||||||||||||||||
| Gli3Mos1/Gli3Mos1 Tg(Dct-lacZ)A12Jkn/0 |
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| Gli3Pdn/Gli3Pdn | ||||||||||||||||||||||||||||||||||||||||||
| Gli3TgBR/Gli3TgBR | ||||||||||||||||||||||||||||||||||||||||||
| Gli3tm1.1Alj/Gli3tm1.1Alj | ||||||||||||||||||||||||||||||||||||||||||
| Gli3Xt-3H/Gli3Xt-3H | ||||||||||||||||||||||||||||||||||||||||||
| Gli3Xt-J/Gli3Xt-J | ||||||||||||||||||||||||||||||||||||||||||
| Gli3Mos1/Gli3+ Tg(Dct-lacZ)A12Jkn/0 |
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| Gli3TgBR/Gli3+ | ||||||||||||||||||||||||||||||||||||||||||
| Gli3tm1.2Zllr/Gli3Xt-J | ||||||||||||||||||||||||||||||||||||||||||
| En1tm2(cre)Wrst/? Gli3tm1Alj/Gli3tm1Alj (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||
| Gli3tm1Alj/Gli3tm1Alj Tg(Nes-cre)1Kln/? (conditional) |
* | |||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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