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Symbol
Name
ID 		Galc
galactosylceramidase
MGI:95636
Phenotype annotations related to nervous system
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Increased CSF protein concentration
Abnormal flash visual evoked potentials
Progressive spasticity
CNS demyelination
Peripheral demyelination
Hydrocephalus
Diffuse cerebral atrophy
Neurodegeneration
EEG abnormality
Decreased nerve conduction velocity
Motor deterioration
Hyperactive deep tendon reflexes
Developmental regression
Sensorimotor neuropathy
Seizure
Disease(s) Associated with GALC
Krabbe disease

Mouse Phenotypes
abnormal blood-brain barrier function
increased oligodendrocyte progenitor number
abnormal glial cell apoptosis
abnormal microglial cell morphology
CNS inflammation
abnormal brain morphology
abnormal brain white matter morphology
abnormal corpus callosum morphology
abnormal cerebellum white matter morphology
abnormal medulla oblongata morphology
abnormal pons morphology
abnormal forebrain morphology
abnormal hindbrain morphology
abnormal astrocyte morphology
astrocytosis
abnormal oligodendrocyte morphology
decreased oligodendrocyte number
gliosis
abnormal axon morphology
abnormal myelin sheath morphology
abnormal sciatic nerve morphology
abnormal spinal cord morphology
abnormal spinal cord white matter morphology
axon degeneration
axonal spheroids
peripheral nervous system degeneration
abnormal nervous system physiology
demyelination
Availability Mouse Genotype
Galctm1Wngr/Galctm1Wngr
Galctwi-5J/Galctwi-5J
Galctwi/Galctwi ! ! ! ! !
Galctwi/Galctwi
Il6+/?
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory