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Symbol Name ID |
Gabrg2
gamma-aminobutyric acid type A receptor, subunit gamma 2 MGI:95623 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Delayed CNS myelination |
Reduced cerebral white matter volume |
Choreoathetosis |
EEG with polyspike wave complexes |
EEG with spike-wave complexes (>3.5 Hz) |
Absent speech |
Addictive alcohol use |
Epileptic encephalopathy |
Severe global developmental delay |
Bilateral tonic-clonic seizure |
Focal impaired awareness seizure |
Generalized non-motor (absence) seizure |
Atypical absence seizure |
Typical absence seizure |
Febrile seizure (within the age range of 3 months to 6 years) |
Atonic seizure |
Infantile spasms |
Myoclonic seizure |
Tonic seizure |
| Disease(s) Associated with GABRG2 | |||||||||||||||||||
| alcohol dependence | |||||||||||||||||||
| developmental and epileptic encephalopathy 74 | |||||||||||||||||||
| familial febrile seizures 8 |
| Mouse Phenotypes | nervous system phenotype |
decreased susceptibility to pharmacologically induced seizures |
increased susceptibility to pharmacologically induced seizures |
seizures |
myoclonus |
tonic-clonic seizures |
febrile seizures |
absence seizures |
abnormal synapse morphology |
abnormal nervous system electrophysiology |
abnormal brain wave pattern |
abnormal neuron physiology |
abnormal GABA-mediated receptor currents |
abnormal inhibitory postsynaptic currents |
abnormal miniature inhibitory postsynaptic currents |
decreased miniature inhibitory postsynaptic current amplitude |
increased miniature inhibitory postsynaptic current amplitude |
increased miniature inhibitory postsynaptic current frequency |
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| Availability | Mouse Genotype | ||||||||||||||||||
| Gabrg2tm1Geh/Gabrg2tm1Geh | |||||||||||||||||||
| Gabrg2tm1Lusc/Gabrg2tm1Lusc | * | ||||||||||||||||||
| Gabrg2tm1Spet/Gabrg2tm1Spet | |||||||||||||||||||
| Gabrg2tm1.1Stmo/Gabrg2+ | |||||||||||||||||||
| Gabrg2tm1.2Rmac/Gabrg2+ | |||||||||||||||||||
| Gabrg2tm1Spet/Gabrg2+ | ! | ||||||||||||||||||
| Gabrg2tm2Spet/Gabrg2+ | |||||||||||||||||||
| Gabrg2tm1Wul/Gabrg2tm1Wul Tg(Pcp2-cre)2Mpin/? (conditional) |
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| Gabrg2tm1Wul/Gabrg2tm1Wul Tg(Pcp2-cre)2Mpin/? Tg(Pcp2-EGFP/Gabrg2)1Wul/? (conditional) |
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| Gabrg2tm1Wul/Gabrg2tm1Wul Hdctm1.1(icre)Wwis/Hdc+ (conditional) |
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| Gabrg2tm2Lusc/Gabrg2tm2Lusc Tg(Camk2a-cre)2834Lusc/0 (conditional) |
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| Gabrg2tm2Spet/Gabrg2+ Tg(Camk2a-tTA)1Mmay/0 Tg(tetO-cre)LC1Bjd/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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