|
Symbol Name ID |
Drd2
dopamine receptor D2 MGI:94924 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Addictive alcohol use |
| Disease(s) Associated with DRD2 | |
| alcohol dependence |
| Mouse Phenotypes | nervous system phenotype |
increased susceptibility to pharmacologically induced seizures |
adenohypophysis peliosis |
increased susceptibility to neuronal excitotoxicity |
increased susceptibility to dopaminergic neuron neurotoxicity |
abnormal neuronal migration |
abnormal pituitary gland morphology |
abnormal adenohypophysis morphology |
decreased gonadotroph cell number |
decreased lactotroph cell size |
increased lactotroph cell number |
decreased somatotroph cell number |
increased thyrotroph cell number |
adenohypophysis hyperplasia |
adenohypophysis hypertrophy |
increased pituitary gland weight |
enlarged pituitary gland |
pituitary gland hyperplasia |
abnormal melanotroph morphology |
enlarged pituitary intermediate lobe |
pituitary intermediate lobe hyperplasia |
increased pituitary adenoma incidence |
abnormal pituitary gland physiology |
microgliosis |
abnormal brain development |
astrocytosis |
abnormal GABAergic neuron morphology |
abnormal astrocyte physiology |
abnormal nervous system electrophysiology |
abnormal single cell response |
abnormal neuron physiology |
abnormal CNS synaptic transmission |
abnormal excitatory postsynaptic currents |
abnormal inhibitory postsynaptic currents |
abnormal prepulse inhibition |
absent long-term depression |
abnormal synaptic dopamine release |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||
| Drd2tm1Ebo/Drd2tm1Ebo | ||||||||||||||||||||||||||||||||||||||
| Drd2tm1Low/Drd2tm1Low | * | |||||||||||||||||||||||||||||||||||||
| Drd2tm1Mok/Drd2tm1Mok | ||||||||||||||||||||||||||||||||||||||
| Drd2tm1.1Mrub/Drd2tm1.1Mrub Slc6a3tm1.1(cre)Bkmn/Slc6a3+ (conditional) |
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| Drd2tm1.1Mrub/Drd2tm1.1Mrub Tg(Nes-cre)1Kln/? (conditional) |
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| Drd2tm1Smoc/Drd2tm1Smoc Tg(GFAP-cre)25Mes/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||
| Drd2tm3.1Ebo/Drd2tm3.1Ebo En1tm2(cre)Wrst/En1+ (conditional) |
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| Drd2tm3.1Ebo/Drd2tm3.1Ebo Tg(Drd1a-cre)AGsc/0 (conditional) |
* | |||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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